Topping the bill are a pair of title fights, including the main event, which sees undefeated welterweight champion Eric Alequin (7-0) putting his belt on the line for the first time when he takes on the hard-hitting Charles "Chuck Buffalo" Radtke (5-3). Meanwhile, the co-feature sees former CFFC flyweight champion Santo Curatolo (6-2) return to the promotion after an appearance on Dana White's Contender Series to contest for an interim flyweight belt against veteran contender Lloyd "Albie" McKinney (15-8).
An additional featured matchup sees Bryan "The Ecuadorian Warrior" Bautista (4-1) take on Brazilian promotional newcomer Gonzalo Ojeda (3-1) in a key featherweight matchup.
The event streams live on UFC FIGHT PASS.
"Our previous events at the incredible Seminole Hard Rock Hotel & Casino Tampa were both phenomenal nights made even more special by the amazing sold-out crowds in attendance," CFFC CEO Rob Haydak said. "We're bringing another lineup full of MMA's next big stars, and we're expecting another evening of action-packed entertainment from start to finish."
A Brazilian jiu-jitsu black belt who remains an active competitor in the grappling world, Florida's Alequin made his CFFC debut in March, battling to a hard-fought decision win over Hugh Pulley to claim the welterweight title left vacant when former titleholder Yohan Lainesse was signed by the UFC. He'll now look to defend the belt against Radtke, who has won back-to-back appearances in the CFFC cage after leaving the lightweight division behind and moving up to 170 pounds.
Meanwhile, Curatolo is an impressive 6-1 under the CFFC banner but now faces the incredibly experienced McKinney for an interim belt, as reigning flyweight champion Phumi Nkuta remains sidelined from surgery he underwent earlier this year.
Current All Elite Wrestling champion and two-time UFC veteran CM Punk calls the action at CFFC 110 alongside Mixed Martial Arts.com editor-in-chief John Morgan on UFC FIGHT PASS.